The strategic vision of the department Myeloid Cell Immunology is to use the heterogeneity of myeloid cells (MCs, mainly monocytes, macrophages and dendritic cells) as an in vivo sensor to track inflammatory responses, in particular in the liver (Kupffer cells) and tumors (subsets of tumor-associated macrophages) and as a target for therapeutic intervention.
- Molecular and functional characterization of distinct tumor-associated macrophage (TAM) subsets. Read more
- Molecular and functional characterization of distinct tumor-associated tissue eosinophil (TATE) subsets.
- Molecular and functional characterization of distinct Myeloid-derived Suppressor Cell (MDSC) subsets.
- Functional characterization of novel markers for M2 and M1 macrophages, including E-cadherin.
- Identification and validation of MC markers for in vivo monitoring and targeting of MCs during chronic inflammatory diseases, including cancer. In this context, MC marker-specific nanobodies are important tools.
- Heterogeneity, dynamics and functionality of liver MC, such as Kupffer cells